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The science of Daily Restore

Why two glasses hit harder than they used to.

It isn't in your head, and you don't have to quit. This page goes deeper than anywhere else on our site: what a night of drinking does to your body, hour by hour, why each ingredient is in 1 Daily Dose, and the full story of our 12-week study, week by week.

Study: 12 weeks, 40 adults
Run with: A third-party clinical research company
Formula reviewed by: Dr. Brooke Scheller

01 · A night with two glasses

What your body does while you sleep it off.

Two glasses of wine at dinner. Here's what happens next, and why you feel it in the morning.

7 p.m.
The first glass
Alcohol passes into your blood and on to your liver, which handles about 95% of what you drink.
9 p.m.
The second glass waits its turn
Your liver clears roughly one standard drink an hour. Anything beyond that keeps circulating until it can catch up.
Midnight
The real work starts
Your liver turns alcohol into acetaldehyde, a toxic compound, then breaks that down. It draws on glutathione, its main antioxidant, to do it.
3 a.m.
Wide awake
Alcohol can help you fall asleep, but as it wears off, sleep in the second half of the night gets lighter and more broken.
7 a.m.
You feel it
Heavier, foggier, slower to get going. Alcohol can also interfere with how you absorb B vitamins your brain and energy depend on.

Why it's harder now

As we get older, our bodies hold less water, so the same glass leads to a higher blood alcohol level, and we clear it more slowly. That's why two glasses can hit harder at 55 than they did at 30.

So why every day?

Most fixes show up after the damage. 1 Daily Dose is already there.

Several of Daily Restore's ingredients build up over time. Taking it every day, including days you don't drink, keeps the nutrients alcohol drains topped up, so your body isn't starting from empty when you do drink.

	Morning-after fix	1 Daily Dose
When	After you already feel it	Every day, before you need it
Your liver	Usually not part of the plan	Milk thistle, NAC and DHM, every day
Nutrients	A one-off top-up, if any	B1, B12 and folate kept steady
Sleep and mood	Rarely addressed	5-HTP, L-tyrosine, L-theanine and ashwagandha

02 · Every ingredient, and its research

What's in 1 Daily Dose, why that form, and what the research shows.

Not just a list of names. For each ingredient: the form we chose, why it matters to you, and the kind of research behind it.

IngredientWhy it matters to youWhat the research shows

01 · Supports your liver

Milk thistle80% silymarin · in blendYour liver takes the strain of every drink.Review of trialsA 2025 review of 55 studies with 3,545 people found silymarin lowered ALT and AST.¹

DHMvine tea, 98% · in blendSupports your liver while it breaks alcohol down.Human trialIn a 3-month placebo-controlled trial of 60 adults, DHM lowered ALT, AST and GGT.²

NACin blendAlcohol uses up glutathione, your liver's main antioxidant.How it worksYour body uses NAC to make glutathione.

02 · Replaces what alcohol drains

Vitamin B1500 mg benfotiamineLow B1 shows up as fatigue and fog.Human trialsMore B1 reaches your body than from standard thiamine.³ Well tolerated by heavy drinkers at 600 mg a day for 24 weeks.⁴

Vitamin B12500 mcg methylcobalaminAlcohol can interfere with how you absorb B12.Established nutrientThe active form, ready for your body to use. Needed for energy and healthy nerves.

Active folate680 mcg DFEWorks alongside B12.Established nutrientThe active form of folate, needed to make new cells.

03 · Steadies mood and focus

5-HTPgriffonia seed, 99% · in blendAlcohol can throw off serotonin, which affects mood and sleep.Human trialStudied for sleep quality in a 2024 randomized trial in older adults.⁵

L-theaninein blendThe day after often brings tension.Human trialStudied for stress and sleep in a placebo-controlled trial of 30 adults.⁶

Ashwagandharoot · in blendAlcohol can raise cortisol, your stress hormone.Human trialStudied for stress in a placebo-controlled trial of 64 adults.⁷

L-tyrosinein blendRegular drinking can leave you flat and unfocused.Human trialStudied for focus and working memory under demanding conditions.⁸

“Supplements hide how little is inside.”

Fair. Every ingredient is named on our label. The B vitamins are listed at full dose. The other seven share a 1,600 mg blend in every Daily Dose. Ingredient research shows why each one belongs; our own study, next, tested the finished formula. See the Supplement Facts

03 · Our study, week by week

Most people felt it within the first month.

40 adults who drink took 1 Daily Dose every day for 12 weeks and answered the same questions at the start and at weeks 4, 8 and 12. Here's how their answers moved.

Length: 12 weeks, 4 check-ins
People: 40 adults, 23 women and 17 men, ages 27 to 68
Run with: A third-party clinical research company
Measured: Next-day symptoms, plus AST, ALT and GGT at the start and week 12

How often people woke up refreshed after drinkingFrom “rarely” to between “sometimes” and “often”.

How noticeable next-day tiredness wasFrom “moderate to distracting” to “barely noticeable”.

Average answers at each check-in, on the study's own five-point scales. Everyone took Daily Restore, and each person was compared with their own starting point.

What we asked, and what people said at week 12.

We asked about	The question, in the study's words	Reported better
Waking refreshed	“How often did you wake feeling refreshed after a night in which you consumed alcohol?”	92%
Next-day tiredness	“How noticeable was your next-day tiredness or fatigue after drinking alcohol?”	83%
Sleep	“How noticeable was your poor or unrestful sleep after consuming alcohol?”	83%
Recovery	“How often did you feel that you recovered well by the next day after drinking alcohol?”	83%
Concentration	“How noticeable was your difficulty concentrating or thinking clearly the day after drinking alcohol?”	81%
Satisfaction	“I am satisfied with the overall results of this product.”	86%
Would recommend	“I would recommend these products to my friends and family.”	83%

“Couldn't people just feel better because they expected to?”

A fair question. That's why the study also took blood at the start and at week 12. Of the 24 people with both tests, 17 saw at least one liver enzyme (AST, ALT or GGT) come down. Most people started in a healthy range, so there was little room to move, and the group averages stayed there. GGT came down the most.

17 of 24saw at least one liver enzyme come down

What comes next

The research company is locking the final data now. When the full report is ready, we'll publish it here, including every measure, not just the best ones.

Survey percentages: the 36 people with surveys at the start and week 12. Charts: average answers at each check-in, August 2026 data. Blood: the 24 people with both blood tests. Study CLOUD-69009. Individual results vary.

04 · How to read your liver panel

Three numbers worth knowing.

Your doctor's routine blood work usually includes them. Here's what they mean, so the next report makes sense.

ALT

The liver's own signal

An enzyme found mostly in liver cells. When liver cells are under strain, more of it shows up in your blood.

AST

A wider signal

Found in the liver and also in muscle, so a hard workout before a test can nudge it up too.

GGT

The one alcohol moves most

Often rises with regular drinking and with some medications. It's on our at-home test.

Every lab prints its own normal range next to your result. Look at where you sit in that range, and how it changes from one test to the next.

A real example

Lori, 63, retested about three months after starting.

“Lab results are amazing!! My AST, ALT and GGT have all returned to normal for the first time in 2 years!!”Lori · Verified customer · Changed nothing else

See more customer results

Marker	Before	After
AST	116	34
ALT	107	37
GGT	233	66

05 · Run your own 12 weeks

The best study is the one you run on yourself.

Do what our participants did, with your own numbers.

1
Take a baseline
Our at-home blood test checks GGT, hsCRP, B12, ferritin and more. Upper-arm collection, no finger prick.
2
1 Daily Dose for 12 weeks
Every day, including days you don't drink. Notice your mornings at weeks 4 and 8.
3
Retest and compare
Same test, same time of day. Your two reports side by side.

Shop Daily Restore Add the blood test · $139180-day money-back guarantee, even on opened bottles

06 · Who's behind the science

Three groups, three different jobs.

Reviewed the formula

Dr. Brooke Scheller

Doctor of Clinical Nutrition and author of How to Eat to Change How You Drink. She reviewed the ingredients and forms in Daily Restore.

Studied it

A third-party research company

A clinical research company that runs studies for supplement brands. They ran the study: enrollment, check-ins and blood tests.

1,094

Recommend it

Clinicians on FrontrowMD

Clinicians who share Daily Restore with their patients through FrontrowMD, without being paid to.

Made in the USAWith globally sourced ingredients.

GMP facilityMade in a facility that follows Good Manufacturing Practices.

Lab testedTested by an ISO/IEC 17025-accredited laboratory.

Vegan capsulesPlant-based. 30 Daily Doses per bottle.

07 · Questions about the science

The questions a careful buyer asks.

Was the study placebo-controlled?

No. Everyone took Daily Restore, and each person was compared with their own starting point. It shows what changed while people took the finished formula. Several ingredients have their own placebo-controlled trials, listed above.

What does “92% woke up refreshed more often” mean?

92% of participants answered that they woke refreshed more often at week 12 than at the start. It counts how many people improved, not how much each person improved. The charts above show how much.

Why benfotiamine instead of regular B1?

More of it reaches your body. In a human absorption study, benfotiamine delivered more thiamine than standard thiamine.

Does it work for everyone?

No supplement does. In our study, nearly everyone reported fewer next-day symptoms, and 17 of 24 people with blood tests saw at least one liver enzyme come down. If it isn't for you, our 180-day guarantee covers you, even on opened bottles.

Can I take it with my medications?

Bring the Supplement Facts to your doctor or pharmacist. Ask especially if you take medication for mood or sleep, because Daily Restore contains 5-HTP, which your body uses to make serotonin.

Judge it by your mornings, and your numbers.

Take 1 Daily Dose for 12 weeks. If you don't feel the difference, you have 180 days to get your money back, even on opened bottles.

Shop Daily Restore Or start with your numbers

References: 1. Shahsavari et al., silymarin meta-analysis of randomized trials, BMC Complementary Medicine and Therapies (2025). 2. Chen et al., dihydromyricetin in nonalcoholic fatty liver disease, randomized controlled trial, Pharmacological Research (2015). 3. Xie et al., benfotiamine bioavailability compared with thiamine, Journal of Clinical Pharmacology (2014). 4. Manzardo et al., benfotiamine in alcohol dependence, randomized placebo-controlled trial, Drug and Alcohol Dependence (2013). 5. 5-HTP and sleep quality in older adults, randomized controlled trial, Clinical Nutrition (2024). 6. Hidese et al., L-theanine and stress-related symptoms, randomized controlled trial, Nutrients (2019). 7. Chandrasekhar et al., ashwagandha root extract and stress, randomized placebo-controlled trial, Indian Journal of Psychological Medicine (2012). 8. Thomas et al., tyrosine and working memory, Pharmacology Biochemistry and Behavior (1999). Alcohol metabolism and aging: National Institute on Alcohol Abuse and Alcoholism. Customer results are their own and shared with permission. Individual results vary.