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Liver supplements · Updated October 30, 2026

Best liver supplement for drinkers? Cloud9 vs LiverMD vs Dose. Only one has benfotiamine.

Searching for LiverMD or Dose? Read this first. Alcohol drains vitamin B1, and low B1 shows up as next-day fatigue, low mood and fog. LiverMD has no B1 at all, and Dose doesn't list any. Benfotiamine is the fat-soluble form of B1 your body absorbs about 3.6 times better. Cloud9 Daily Restore has 500 mg, every day, with NAC and milk thistle.

By Mike Hardenbrook, co-founder of Cloud9

Our #1 pick

A+

Cloud9 Daily Restore

The only one with benfotiamine, and the only one built for people who drink.

  • 500 mg of benfotiamine. The premium, fat-soluble form of vitamin B1, absorbed about 3.6 times better than regular B1. LiverMD has no B1 at all, and Dose doesn't list it.
  • Built for drinking. DHM and four sleep and mood ingredients alongside 350 mg each of NAC and milk thistle. Both rivals are general liver support.
  • Premium forms. Methyl B12 and active folate (L-5-MTHF). Neither rival lists any B12 or folate.
  • Clinically studied in people who drink. In our 12-week clinical trial, 3 out of 4 had a decrease in at least one liver enzyme, and 92% woke refreshed more often after drinking.
  • 180-day money-back guarantee, even on empty bottles. LiverMD gives you 90 days, Dose 30 days on a first order.
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4.8 from 664 reviews · from $1.30 a day · free shipping on subscriptions

The difference that matters most

Alcohol drains your B1. Most liver supplements ignore it.

Low thiamine (vitamin B1) is the best-known vitamin deficiency tied to drinking. Your body can't make B1 and only stores a small amount, and alcohol cuts how much you absorb and keep.

The problem with regular B1
Regular B1 (thiamine HCl) is water-soluble. It relies mostly on transporters in your gut to get in, and alcohol impairs those transporters. So drinking cuts how much regular B1 you actually take in.
Why benfotiamine works
Benfotiamine is fat-soluble, so it doesn't depend on those transporters. In human studies it's absorbed about 3.6 times better than regular B1. Daily Restore has 500 mg. LiverMD has none, and Dose doesn't list it.
  • EnergyB1 is what your cells use to turn food into energy. Running low after drinking shows up as next-day fatigue.
  • Mood and focusEarly signs of low B1 include tiredness, irritability and trouble concentrating, the same fog you feel the morning after.
  • NervesIn placebo-controlled trials, benfotiamine improved nerve function, including in people whose nerves had been affected by alcohol.
  • LiverIn lab studies of alcohol exposure, benfotiamine restored thiamine in the liver and reduced liver damage.

Get 500 mg of benfotiamine every day

The other two

#2

B

1MD LiverMD

Solid general liver support, but not built for drinking.

  • No benfotiamine and no B1 of any kind
  • No DHM and nothing for next-day sleep and mood
  • No B12 or folate listed
  • Enzyme claim comes from a 2021 survey of 145 paid repeat customers, not a trial
  • 90-day guarantee, 2 capsules a day

#3

C

Dose for Your Liver

A pricey liquid shot that won't tell you how much of anything is in it.

  • $3.75 a day: $90 for 24 days
  • Ingredient amounts not listed on its product page
  • No benfotiamine or B vitamins listed, and no DHM
  • Studied in healthy adults, while Daily Restore was tested in adults who drink
  • 30-day guarantee, first order only

Side by side

Cloud9 Daily Restore, 1MD LiverMD and Dose for Your Liver compared, from each brand's own product page, October 30, 2026
What mattersCloud9 Daily Restore1MD LiverMDDose for Your Liver
Vitamin forms
Benfotiaminefat-soluble B1, absorbed 3.6 times better500 mgNoneno B1 at allNot listed
Vitamin B12Methyl B12, 500 mcgNoneNot listed
FolateActive L-5-MTHF, 400 mcgNoneNot listed
Built for drinking
Made for people who drinkYesNoNo
DHM200 mgNoneNot listed
Sleep and mood ingredients4NoneNot listed
NAC + milk thistleYes, every amount listedYesAmounts not listed
Proof
How it was tested12-week clinical trial in adults who drink, with bloodworkSurvey of 145 paid customers3-month study in healthy adults
Liver enzyme result, as each brand states it75% had a decrease in at least one enzymein our 12-week clinical trial"Over 80%" report improved enzymessurvey of 145 customers81% ALT, 85% AST "positive impact"study in healthy adults
Cost and terms
Cost per day$1.30 to $1.97$0.98 to $1.63$3.75
Money-back guarantee180 days, even on empty bottles90 days30 days, first order

Read on each brand's own product page, October 30, 2026. "Not listed" means that page doesn't list it.

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Read this before you buy

The catch with general liver supplements

  • They skip the B1Alcohol drains vitamin B1. LiverMD has no B1 at all, and Dose doesn't list any. Daily Restore has 500 mg of benfotiamine, every day.
  • They aren't built for drinkingNeither has DHM or anything for next-day sleep and mood. Daily Restore pairs NAC and milk thistle with DHM and four sleep and mood ingredients.
  • The proof doesn't match youLiverMD's numbers come from a survey of paid customers, and Dose studied healthy adults. Daily Restore was tested in adults who drink, with blood drawn before and after.

Clinically studied in people who drink

An independent clinical research company tested the finished Daily Restore formula in 36 adults who drink, with blood drawn before and after.

75%
Had a decrease in at least one liver enzyme (AST, ALT or GGT), in our 12-week clinical trial.
92%
Woke refreshed more often after drinking, in our 12-week clinical trial.
83%
Had less next-day fatigue after drinking, in our 12-week clinical trial.

Questions people ask

Liver supplements and drinking, answered.

What is the best liver supplement for drinkers?

Cloud9 Daily Restore. It's the only one of these three with benfotiamine: 500 mg of the B1 form your body absorbs about 3.6 times better, and alcohol drains B1. It's built for people who drink, with DHM and four sleep and mood ingredients alongside NAC and milk thistle, and 3 out of 4 had a decrease in at least one liver enzyme in our 12-week clinical trial. It comes with a 180-day money-back guarantee, even on empty bottles.

Do LiverMD or Dose have benfotiamine?

No. LiverMD lists no B1 of any kind, and Dose for Your Liver doesn't list benfotiamine or any B vitamins. Cloud9 Daily Restore has 500 mg of benfotiamine, the fat-soluble form of B1 your body absorbs about 3.6 times better than regular B1.

Benfotiamine vs thiamine HCl: what's the difference?

Thiamine HCl is the cheap, water-soluble form of vitamin B1. It relies mostly on transporters in your gut to get in, and alcohol impairs those transporters. Benfotiamine is fat-soluble, so it doesn't depend on them, and in human studies it's absorbed about 3.6 times better than regular B1. That's why Daily Restore uses 500 mg of benfotiamine.

Why does alcohol drain vitamin B1?

Alcohol cuts how much thiamine (vitamin B1) your gut absorbs and how much your body keeps, and your body can't make its own. Low B1 is the best-known vitamin deficiency tied to drinking. B1 is what your cells use to turn food into energy, so running low shows up as next-day fatigue, irritability and fog.

Cloud9 Daily Restore vs LiverMD: what's the difference?

Daily Restore is built for people who drink: 500 mg of benfotiamine, DHM, methyl B12, active folate and four sleep and mood ingredients, on top of NAC and milk thistle. It was tested as a finished formula with bloodwork in adults who drink, and it has a 180-day guarantee. LiverMD is general liver support with no B1, no DHM and nothing for next-day sleep and mood, its enzyme claim comes from a survey of paid customers, and its guarantee is 90 days.

Cloud9 Daily Restore vs Dose: what's the difference?

Daily Restore is capsules, lists every amount and is built for people who drink, at $1.30 to $1.97 a day. Dose is a liquid shot at $3.75 a day that doesn't list its ingredient amounts or any B vitamins, has no DHM, and comes with a 30-day guarantee on a first order. Daily Restore's guarantee is 180 days, even on empty bottles.

Is LiverMD good if you drink?

LiverMD is built for diet, oxidative stress and environmental toxins, not drinking. It has no benfotiamine to replace the B1 alcohol drains, no DHM for acetaldehyde, and nothing for next-day sleep and mood. If you drink, a formula built for that is the better fit.

Does Dose for Your Liver help with alcohol?

Dose is a daily wellness shot for general liver function, tested in healthy adults. Its page lists no DHM, no benfotiamine and nothing for the morning-after fog. Daily Restore was tested in adults who drink, and 92% woke refreshed more often after drinking in our 12-week clinical trial.

Is Daily Restore worth more than LiverMD?

Plan for plan, it costs about 25 to 35 cents a day more. That buys 500 mg of benfotiamine, DHM, methyl B12, active folate and four sleep and mood ingredients LiverMD doesn't have, a formula tested in a 12-week clinical trial with bloodwork instead of a paid survey, and twice the guarantee: 180 days, even on empty bottles.

NAC vs milk thistle: what's the difference?

They protect your liver in two different ways. NAC (N-acetylcysteine) is the raw material your liver turns into glutathione, its main antioxidant, which helps neutralize acetaldehyde, the toxic byproduct of alcohol. Milk thistle's active compounds, called silymarin, work at the liver cell itself, helping protect cell membranes and supporting repair. Daily Restore has 350 mg of each.

How long until liver enzymes change?

Plan on about 12 weeks. That's how long our clinical trial ran, and 3 out of 4 had a decrease in at least one liver enzyme in our 12-week clinical trial. A simple before-and-after blood test is the best way to see your own numbers.

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Cloud9 Daily Restore

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That's $1.50 a day, about $11 a week. Less than one glass of wine at dinner.

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Written by Mike Hardenbrook, co-founder of Cloud9, the maker of Daily Restore. Competitor facts come only from each brand's own product page, read October 30, 2026: 1md.org/products/livermd (including its Supplement Facts) and dosedaily.co/products/dose-for-your-liver. "Not listed" means that page doesn't list it. Spot something out of date? Email info@trycloud9.com.