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Liver supplements, updated November 3, 2026

Thorne S.A.T. vs Cloud9 Daily Restore. One was built for people who drink.

Searching for Thorne S.A.T.? It's a well-made, three-botanical liver formula: milk thistle, artichoke and turmeric, for liver and digestion support. What it doesn't include is NAC, vitamin B1 or anything for next-day sleep, mood or focus. Daily Restore has all of that in 1 Daily Dose, and it was tested as a finished formula in a 12-week clinical trial.

By Mike Hardenbrook, co-founder of Cloud9

Built for people who drink

Cloud9 Daily Restore

Built for drinking. 350 mg NAC, 350 mg milk thistle and 200 mg DHM, every day.
500 mg benfotiamine. The fat-soluble form of vitamin B1, which alcohol drains. S.A.T. has no B1.
Tested as a finished formula. In our 12-week clinical trial, 3 out of 4 participants had a decrease in at least one liver enzyme, and 92% reported waking refreshed more often after drinking.
Next-day support. Ashwagandha, L-theanine, L-tyrosine and 5-HTP for sleep, mood and focus.
180-day guarantee, covers empty bottles.

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4.8 from 664 reviews · from $1.30 a day · free shipping on 3- and 6-month plans

How Thorne S.A.T. compares

Where it fits

Thorne S.A.T.

Silybin phytosome 150 mg, curcumin phytosome 150 mg and artichoke leaf extract 150 mg per capsule.
$47 for 60 capsules. At its label's 1 capsule two to three times a day, a bottle lasts 20 to 30 days: about $47 to $70.50 a month.
Good for: general liver and digestion support from a trusted brand.
Missing for drinkers: NAC, vitamin B1, DHM, sleep and mood support, and a trial of the finished formula.

Side by side

Cloud9 Daily Restore and Thorne S.A.T. compared, from each brand's own pages, November 3, 2026
What matters	Cloud9 Daily Restore	Thorne S.A.T.
Made for people who drink	Yes	No
NAC	350 mg	None
Milk thistle	350 mgpowder	Silybin phytosome 150 mg
DHM	200 mg	None
Vitamin B1 (benfotiamine)	500 mg	None
B12 and folate	Methyl B12 500 mcg, folate (L-5-MTHF) 400 mcg	None
Sleep and mood ingredients	Yes (4)ashwagandha, L-theanine, L-tyrosine, 5-HTP	None
Clinical trial of the finished formula	Yes, 12 weeks	None on its product page
How you take it	1 Daily Dose4 capsules, once a day	1 capsule, 2 to 3 times a day
Price	$54 a monthor $39/mo on the 6-month plan	$47 for 60 capsules20 to 30 days at its label dose

Read on Thorne's own product page and Supplement Facts, November 3, 2026.

See Daily Restore plans

Doctor-developed, and clinically studied

An independent clinical research company tested the finished Daily Restore formula in adults who drink, with blood drawn before and after.

92%: Woke refreshed more often after drinking, in our 12-week clinical trial.
83%: Had less next-day fatigue after drinking, in our 12-week clinical trial.
75%: Had a decrease in at least one liver enzyme (AST, ALT or GGT), in our 12-week clinical trial.

Questions people ask

Thorne S.A.T. and Daily Restore, answered.

Is Thorne S.A.T. good for drinkers?

It's a general liver formula (milk thistle, artichoke, turmeric). It has no NAC, no vitamin B1 and nothing for next-day sleep or mood, which is what Daily Restore was built around.

Can I take S.A.T. and Daily Restore together?

Both contain milk thistle, so most people pick one. Ask your doctor or pharmacist if you take prescriptions.

What did Daily Restore's trial show?

In our 12-week clinical trial, 3 out of 4 participants had a decrease in at least one liver enzyme (AST, ALT or GGT), and 92% reported waking refreshed more often after drinking.

Which costs less?

At its label dose, a $47 bottle of S.A.T. lasts 20 to 30 days, about $47 to $70.50 a month. Daily Restore is $54 a month, or $39 a month on the 6-month plan, with NAC, B1, DHM and sleep and mood ingredients in the same dose.

Try Daily Restore for 180 days

If it's not for you, get your money back, even on empty bottles.

Cloud9 Daily Restore

4.8 · 664 reviews

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Free US shippingFree shipping at $100+

1-Month Supply $54 every todos os meses$59 one-time ~~$59~~$54/moSave $5$59/mo

3-Month SupplyMost popular $135 every a cada 3 meses$156 one-time ~~$59~~$45/moSave $42~~$59~~$52/moSave $21

6-Month SupplyBest value $240.72 every a cada 6 meses$264 one-time ~~$59~~$39/moSave $113~~$59~~$44/moSave $90

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That's $1.50 a day, about $11 a week. Less than one glass of wine at dinner.

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Written by Mike Hardenbrook, co-founder of Cloud9, the maker of Daily Restore. Thorne's facts come from its own product page, read November 3, 2026: thorne.com/products/dp/s-a-t-reg. Spot something out of date? Email info@trycloud9.com.