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Hangover supplements · Updated October 31, 2026

Best hangover supplement? ZBiotics vs Cheers vs Cloud9. Only one has benfotiamine.

Searching for ZBiotics or Cheers? Read this first. Alcohol drains vitamin B1, and low B1 shows up as next-day fatigue, low mood and fog. Neither of them has benfotiamine, the fat-soluble form of B1 your body absorbs about 3.6 times better. Cloud9 Daily Restore has 500 mg, every day.

By Mike Hardenbrook, co-founder of Cloud9

Our #1 pick

A+

Cloud9 Daily Restore

The only one with benfotiamine, and the only one that's doctor-developed and clinically studied.

  • 500 mg of benfotiamine. The premium, fat-soluble form of vitamin B1, absorbed about 3.6 times better than the regular B1 in Cheers. ZBiotics has no B1 at all.
  • Premium forms, not the cheap ones. Methyl B12, active folate (L-5-MTHF) and NAC, where Cheers uses basic cyanocobalamin, no folate and plain L-cysteine.
  • Doctor-developed and clinically studied. In our 12-week clinical trial, 92% woke refreshed more often after drinking, and 3 out of 4 had a decrease in at least one liver enzyme.
  • Every day, not just the nights you remember. 1 Daily Dose with NAC, milk thistle, DHM and four sleep and mood ingredients, already in place before your first sip.
  • 180-day money-back guarantee, even on empty bottles.
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4.8 from 664 reviews · from $1.30 a day · free shipping on subscriptions

The difference that matters most

Alcohol drains your B1. Regular B1 can't keep up.

Low thiamine (vitamin B1) is the best-known vitamin deficiency tied to drinking. Your body can't make B1 and only stores a small amount, and alcohol cuts how much you absorb and keep.

The problem with regular B1
Thiamine HCl, the cheap form in Cheers, is water-soluble. It relies mostly on transporters in your gut to get in, and alcohol impairs those transporters. So drinking cuts how much regular B1 you actually take in.
Why benfotiamine works
Benfotiamine is fat-soluble, so it doesn't depend on those transporters. In human studies it's absorbed about 3.6 times better than regular B1. Daily Restore has 500 mg. Cheers has 20 mg of regular thiamine. ZBiotics has none.
  • EnergyB1 is what your cells use to turn food into energy. Running low after drinking shows up as next-day fatigue.
  • Mood and focusEarly signs of low B1 include tiredness, irritability and trouble concentrating, the same fog you feel the morning after.
  • NervesIn placebo-controlled trials, benfotiamine improved nerve function, including in people whose nerves had been affected by alcohol.
  • LiverIn lab studies of alcohol exposure, benfotiamine restored thiamine in the liver and reduced liver damage.

Get 500 mg of benfotiamine every day

The other two

#2

B

Cheers Restore

A big DHM dose after you drink, built on cheaper vitamin forms.

  • No benfotiamine: just 20 mg of regular thiamine HCl
  • Basic B12 (cyanocobalamin), no folate, plain L-cysteine instead of NAC
  • Only works on the nights you take it: 3 capsules after your last drink
  • Refund on your first order only, one bottle at most
  • $35 for 12 doses, $2.92 every night you drink

#3

C

ZBiotics Pre-Alcohol

One probiotic, no vitamins, and it only works if you drink it first.

  • No B1 of any kind, nothing for your liver and no sleep ingredients
  • Drink it the morning after and, in ZBiotics' own words, "It probably won't do anything."
  • Its own page says alcohol "will still probably affect your well-being and your sleep."
  • $13 a bottle, or $7.17 to $9 in bulk, every day you drink
  • Refund on your first purchase only

Side by side

Cloud9 Daily Restore, Cheers Restore and ZBiotics Pre-Alcohol compared, from each brand's own pages, October 31, 2026
What mattersCloud9 Daily RestoreCheers RestoreZBiotics Pre-Alcohol
Vitamin forms
Benfotiaminefat-soluble B1, absorbed 3.6 times better500 mgNone20 mg regular thiamine HClNoneno B1 at all
Vitamin B12Methyl B12, 500 mcgCyanocobalamin, 100 mcgNone
FolateActive L-5-MTHF, 400 mcgNoneNone
CysteineNAC, 350 mgPlain L-cysteineNone
How it works
How you take it1 Daily Dose, every day3 capsules after your last drink1 bottle before your first drink
Still works if you forgetYes, it's already in placeNoNo"probably won't do anything" the morning after
Daily liver supportNAC + milk thistleMilk thistle, no NACNone
Sleep and mood ingredientsDHM + 4 moreDHM onlyNone
Proof
Doctor-developedYesNot statedNot stated
Clinical trial of the product, with bloodworkYes, 12 weeksNone on its product pageNone on its product page
The morning after, in each brand's words92% woke refreshed more oftenin our 12-week clinical trial"Feeling like you drank roughly half the amount"Alcohol "will still probably affect your well-being and your sleep"
Cost and terms
Cost$1.30 to $1.97 a day, every day covered$2.92 a night$7.17 to $13 a night
Money-back guarantee180 days, even on empty bottlesFirst order, 1 bottleFirst purchase

Read on each brand's own pages and Supplement Facts, October 31, 2026. Quotes are theirs, word for word.

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Read this before you buy

The catch with one-night hangover products

  • They skip the B1Alcohol drains vitamin B1 every time you drink. ZBiotics has none, and Cheers uses 20 mg of regular thiamine HCl, the cheap form drinking cuts the absorption of. Daily Restore has 500 mg of benfotiamine, every day.
  • You have to rememberZBiotics has to be your first drink of the night, and Cheers has to go down after your last one. Miss the window and you get nothing. Daily Restore is taken once a day, so it's already working before you pour.
  • Your liver is an afterthoughtCheers Restore has no NAC, and ZBiotics has nothing for your liver at all. Daily Restore gives your liver 350 mg each of NAC and milk thistle, every day, and 3 out of 4 had a decrease in at least one liver enzyme in our 12-week clinical trial.

Doctor-developed, and clinically studied

An independent clinical research company tested the finished Daily Restore formula in 36 adults who drink, with blood drawn before and after.

92%
Woke refreshed more often after drinking, in our 12-week clinical trial.
83%
Had less next-day fatigue after drinking, in our 12-week clinical trial.
75%
Had a decrease in at least one liver enzyme (AST, ALT or GGT), in our 12-week clinical trial.

Questions people ask

Hangover supplements, answered.

What is the best hangover supplement?

Cloud9 Daily Restore. It's the only one of these three with benfotiamine: 500 mg of the B1 form your body absorbs about 3.6 times better. It's doctor-developed and clinically studied, it works every day instead of one night at a time, and in our 12-week clinical trial 92% woke refreshed more often after drinking. It comes with a 180-day money-back guarantee, even on empty bottles.

Do ZBiotics or Cheers have benfotiamine?

No. ZBiotics has no B1 of any kind. Cheers Restore has 20 mg of thiamine HCl, the regular water-soluble form. Cloud9 Daily Restore has 500 mg of benfotiamine, the fat-soluble form your body absorbs about 3.6 times better.

Benfotiamine vs thiamine HCl: what's the difference?

Thiamine HCl is the cheap, water-soluble form of vitamin B1. It relies mostly on transporters in your gut to get in, and alcohol impairs those transporters. Benfotiamine is fat-soluble, so it doesn't depend on them, and in human studies it's absorbed about 3.6 times better than regular B1. That's why Daily Restore uses 500 mg of benfotiamine instead of thiamine HCl.

Why does alcohol drain vitamin B1?

Alcohol cuts how much thiamine (vitamin B1) your gut absorbs and how much your body keeps, and your body can't make its own. Low B1 is the best-known vitamin deficiency tied to drinking. B1 is what your cells use to turn food into energy, so running low shows up as next-day fatigue, irritability and fog.

Does ZBiotics work?

ZBiotics is a probiotic built to break down acetaldehyde in your gut, and only if you drink it first. Its own FAQ says that if you drink it the morning after, "It probably won't do anything," and its product page says alcohol "will still probably affect your well-being and your sleep." It has no B1, nothing for your liver and no sleep ingredients.

What's the best ZBiotics alternative?

Daily Restore. Instead of one bottle you have to remember before your first drink, it's 1 Daily Dose that's already working when you have a drink. It adds what ZBiotics doesn't have: 500 mg of benfotiamine, liver support and sleep support. And it costs $1.30 to $1.97 a day, against $7.17 to $13 for each bottle of ZBiotics.

Is Cheers Restore worth it?

Cheers Restore is a large dose of DHM you take after your last drink, built on cheaper vitamin forms: 20 mg of regular thiamine HCl instead of benfotiamine, basic cyanocobalamin B12, no folate, and plain L-cysteine instead of NAC. It only helps on the nights you take it, and its refund covers your first order and one bottle only. Daily Restore covers every day with 500 mg of benfotiamine, methyl B12, active folate and NAC, and a 180-day guarantee.

ZBiotics vs Cheers: which is better?

Cheers does more than ZBiotics: DHM, cysteine and vitamins against a single probiotic, and it costs less per night ($2.92 against $7.17 to $13). But neither has benfotiamine, and both are one-night products you have to time right. If you want 500 mg of benfotiamine, the B1 absorbed about 3.6 times better, every day, Daily Restore beats both.

Should I take Daily Restore before or after drinking?

Take it every day, whether you drink that day or not. Your benfotiamine and NAC work best when your stores are already full before alcohol arrives, and milk thistle works best taken daily so the support is steady. That way you never have to remember a pill before your first drink or after your last.

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Cloud9 Daily Restore

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That's $1.50 a day, about $11 a week. Less than one glass of wine at dinner.

Better mornings, or your money back.Take it for up to 180 days. If it's not for you, get your money back, even on opened bottles.

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Written by Mike Hardenbrook, co-founder of Cloud9, the maker of Daily Restore. Competitor facts and quotes come from each brand's own pages, read October 31, 2026: zbiotics.com/products/zbiotics, zbiotics.com/pages/faqs, cheershealth.com/products/restore (including its Supplement Facts) and cheershealth.com/policies/refund-policy. Spot something out of date? Email info@trycloud9.com.