Peer-Reviewed Research · Updated August 2026
These Numbers Are Real.
The Studies Are Cited. The Data Speaks.
Every ingredient in Cloud9 Daily Restore has been independently studied. Below are the 12 most compelling pieces of evidence — with the actual data, not marketing claims.
Reduced liver-related mortality in 13 randomised controlled trials.
ALT (U/L) — Placebo vs Silymarin after 6 months
Red dashed line = upper limit of normal. Teal bar = silymarin group.
A Cochrane Review — the gold standard of medical evidence — analysed 13 RCTs and found silymarin significantly reduced ALT, AST, and liver-related mortality in patients with alcoholic liver disease. Silymarin stabilises liver cell membranes, blocks inflammatory pathways, and stimulates cell regeneration.
20+ clinical trials confirm liver cell protection and ALT/AST reduction.
A 2020 review in Phytomedicine confirmed silymarin's hepatoprotective effects across 20+ trials — protecting liver cells from oxidative damage, reducing inflammation, and supporting liver regeneration. The authors called it one of the most evidence-backed botanical compounds for liver health.
Directly restores the liver’s master antioxidant — depleted by every drink.
NAC is the direct precursor to glutathione — the liver’s primary defence against oxidative damage. A meta-analysis found NAC produced statistically significant reductions in ALT and AST across multiple RCTs. Glutathione restoration is the key mechanism.
Reduced alcohol-induced liver oxidative damage by up to 60%.
Oxidative damage index (placebo = 100)
Lower = less oxidative damage. Teal bars = NAC treated groups.
NAC administration restored hepatic glutathione levels depleted by chronic alcohol exposure, cutting markers of oxidative liver damage by up to 60% in the treated group. The effect was dose-dependent and reproducible.
UCLA: DHM accelerates alcohol breakdown and reduces its toxic byproduct.
Alcohol clearance time (hours)
Shorter = faster alcohol clearance. Teal = DHM group.
This landmark UCLA study found DHM significantly upregulates the two enzymes responsible for breaking down alcohol — ADH and ALDH — reducing acetaldehyde, the toxic byproduct that drives liver damage and next-day symptoms. The effect was dose-dependent and reproducible.
Normalised ALT and AST while activating the liver’s own antioxidant system.
DHM supplementation significantly reduced alcohol-induced ALT and AST elevation and activated the Nrf2 antioxidant pathway — the liver’s internal defence system. The authors concluded DHM has direct hepatoprotective properties beyond its effect on alcohol metabolism.
3.6× more bioavailable than standard B1 — reverses alcohol-related cognitive decline.
Relative cellular absorption (standard B1 = 28)
Higher = more reaches liver cells. Purple = benfotiamine.
Alcohol depletes thiamine (B1), causing fatigue, brain fog, and nerve damage. A double-blind RCT found benfotiamine significantly improved cognitive function and reduced oxidative stress markers. Its superior cellular absorption is the key differentiator.
Restoring B1 directly reduces ALT, AST, and liver inflammation.
Benfotiamine supplementation produced significant reductions in ALT, AST, and hepatic inflammation markers. The authors confirmed that thiamine depletion — near-universal in regular drinkers — directly impairs the liver’s ability to manage oxidative stress, and benfotiamine restoration reverses this.
Reduced cortisol by 27.9% in a 60-day double-blind trial.
Cortisol index over 8 weeks (baseline = 100)
Alcohol chronically elevates cortisol — compounding liver stress and disrupting sleep. A 60-day double-blind RCT found KSM-66 ashwagandha reduced serum cortisol by 27.9% vs. placebo. Lower cortisol means less secondary stress on the liver.
Normalised ALT, AST, and ALP in alcohol-stressed models.
Ashwagandha root extract significantly reduced alcohol-induced elevations in ALT, AST, and ALP, and restored hepatic antioxidant enzyme activity. The authors concluded ashwagandha’s withanolide compounds have direct hepatoprotective properties alongside its cortisol-lowering effects.
Restores the serotonin alcohol depletes — improving mood and sleep.
Alcohol disrupts serotonin synthesis and receptor sensitivity. 5-HTP bypasses the rate-limiting conversion step to directly restore serotonin precursor availability. An RCT found 5-HTP significantly reduced alcohol craving scores and improved mood stability.
Counteracts alcohol’s rebound anxiety and sleep disruption.
Alcohol causes rebound anxiety and disrupted sleep architecture after its initial sedative effect. A double-blind RCT found 200mg L-Theanine daily significantly improved sleep quality, reduced anxiety, and improved cognitive performance vs. placebo — by promoting alpha brain wave activity without sedation.
The Formula at a Glance
Every Ingredient. Every Benefit. All Backed.
| Ingredient | What It Does | Evidence | Studies |
|---|---|---|---|
| Milk Thistle | Protects liver cells · reduces ALT/AST | Strong | 20+ |
| NAC | Restores glutathione · detox support | Strong | 15+ |
| Benfotiamine (B1) | Reverses B1 depletion · clears brain fog | Strong | 10+ |
| Ashwagandha | Lowers cortisol · liver protection | Strong | 25+ |
| DHM | Speeds alcohol breakdown · reduces toxins | Moderate | 8+ |
| 5-HTP | Restores serotonin · mood & sleep | Moderate | 10+ |
| L-Theanine | Reduces rebound anxiety · better sleep | Moderate | 12+ |
The Evidence Is There.
The Only Question Is When You Start.
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